Informazioni
Non ci sono recensioni
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Bone Drugs in Pediatrics
Efficacy and Challenges
Klein
Editore
Springer
Anno
2014
Pagine
233
ISBN
9781489974358
103,00 €
- Presents evidence for the use of certain drugs in the treatment and prevention of bone loss in children
- Balances the pros and cons of utilizing these drugs in the pediatric population
- Highlights the potential for future use of these and other drugs with children
Bone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves – such as bisphosphonates, anti-resorptives and anabolic agents – within the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs in future treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.
Contents
1 Introduction ............................................................................................. 1
Gordon L. Klein
2 Developmental Pharmacokinetics:
Drug Disposition Relative to Age ........................................................... 5
Michael D. Reed and Michelle L. Bestic
3 Drug Development for Pediatric Diseases with Bone Loss ................. 23
Chi Zhang
4 Paediatric Bone Physiology and Monitoring the Safety
and Effi cacy of Bone Drugs in Children ............................................... 37
John G. Logan, J. H. Duncan Bassett, and Moira S. Cheung
5 Bisphosphonates in Osteogenesis Imperfecta ....................................... 67
Andrew Biggin and Craig F. Munns
6 Use of Bisphosphonates in Genetic Diseases
Other than Osteogenesis Imperfecta ..................................................... 81
Maria Luisa Bianchi
7 Bisphosphonates in Pediatric Burn Injury ........................................... 101
Gordon L. Klein
8 Growth Hormone and Bone ................................................................... 117
Daisuke Harada and Yoshiki Seino
9 Growth Hormone and Oxandrolone in Burned Children ................... 135
Nigel Tapiwa Mabvuure, Alexis N. Thomas,
and Linda E. Sousse
10 Pediatric Bone Drugs: Calcium and Vitamin D ................................... 153
Melissa S. Putman and Catherine M. Gordon
11 Pediatric Maxillofacial Conditions and Drugs ..................................... 183
Srinivas M. Susarla, Christina M. Jacobsen,
and Shelly Abramowicz
12 Newer Adult Bone Drugs ........................................................................ 199
Natalie E. Cusano, Aline G. Costa, Barbara C. Silva,
and John P. Bilezekian
13 Conclusion: Whither (or Wither?) the Pharmacology
of Pediatric Bone? ................................................................................... 223
Gordon L. Klein
Index ................................................................................................................. 225
