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Evolution of the Skeleton
Pages 3-9
This comprehensive guide covers the investigation, diagnosis, prevention, and therapy of all the bone disorders encountered in medical practice. Written in an easy-to-read style, it updates physicians on the current knowledge of bone structure, physiology, and pathology, with emphasis on the diagnosis and treatment of common bone diseases. Today, both medical practitioners and specialists need quick access to information on “bone problems” in order to help patients and their families. Therefore this book deals with everything from the basic physiology of bone and mineral metabolism to the utility of radiologic imaging and specialized tests in bone diagnosis and current treatment recommendations. It is scientifically based but provides clear guidelines for managing bone problems and for lifelong maintenance of skeletal structure and function. It will assist not only in the delivery of effective treatment but also in disease prevention.
Evolution of the Skeleton
Pages 3-9
Structure and Architecture of Bone
Pages 11-20
Modelling and Remodelling of Bone
Pages 21-30
Control and Regulation of Bone Remodelling
Pages 31-38
Growth and Ageing of Bone
Pages 39-41
Osteoclast: The Leading Actor in Bone Disorders
Pages 45-47
Classifying Bone Disorders According to Spread (Topography)
Pages 49-49
Classifying Bone Disorders According to Underlying Pathologic Anatomy
Pages 51-54
Classifying Bone Disorders According to Pathophysiology
Pages 55-59
Clinical Evaluation
Pages 63-64
Skeletal Imaging
Pages 65-67
Essentials of Skeletal Radiology
Pages 69-84
Bone Densitometry
Pages 85-91
Laboratory Investigations
Pages 93-96
Bone and Bone Marrow Biopsy
Pages 97-102
Epidemiology of Osteoporosis
Pages 105-108
Definition of Osteoporosis
Pages 109-110
Pathogenesis of Osteoporosis
Pages 111-113
Subgroups of Osteoporosis
Pages 115-121
Clinical Evaluation of Osteoporosis
Pages 123-134
Risk Factors for Osteoporosis and Fractures
Pages 137-147
A Step-by-Step Programme for Healthy Bones
Pages 149-160
Physical Activity and Exercise Programmes
Pages 161-163
Calcium and Other Minerals
Pages 167-170
Vitamin D and Other Useful Vitamins
Pages 171-176
Hormone Replacement Therapy (HRT)
Pages 177-183
Management of Pain in Osteoporosis
Pages 187-189
Treatment Strategies in Osteoporosis
Pages 191-194
Bisphosphonates (BP)
Pages 195-210
Other Drugs in Osteoporosis
Pages 211-220
Adherence and Monitoring of Osteoporosis Therapy
Pages 221-225
Future Directions
Pages 227-230
Epidemiology of Osteoporotic Fractures
Pages 233-234
Risk Factors of Osteoporotic Fractures
Pages 235-238
Fracture Healing
Pages 239-242
Management of Osteoporotic Fractures
Pages 243-256
Fractures in Rare Bone Disorders
Pages 257-259
Falls and Fall Prevention
Pages 261-261
Osteoporosis in Men
Pages 265-269
Osteoporosis in Children and Adolescents
Pages 271-279
Premenopausal Osteoporosis
Pages 281-282
Pregnancy-Associated Osteoporosis
Pages 283-286
Immobilisation Osteoporosis (Disuse Osteoporosis, Disuse Atrophy)
Pages 287-289
Assessment of Secondary Osteoporosis
Pages 293-294
Cardiology
Pages 295-296
Endocrinology
Pages 297-299
Gastroenterology
Pages 301-302
Genetics
Pages 303-303
Haematology and Storage Disorders
Pages 305-309
Infectious Disorders
Pages 311-311
Nephrology
Pages 313-314
Neurology and Psychiatry
Pages 315-316
Oncology
Pages 317-318
Pulmonology
Pages 319-319
Rheumatology and Immunology
Pages 321-322
The Patient with “Hypocalcaemia”
Pages 325-327
Osteomalacia and Rickets
Pages 329-334
AIDS Osteopathy
Pages 335-339
The Patient with “Hypercalcaemia”
Pages 341-343
Primary Hyperparathyroidism (pHPT)
Pages 345-349
The Patient with “Dense Bones”
Pages 351-354
Osteosclerosis and Hyperostosis
Pages 355-359
The Patient with “Changes in the Shape of Bones”
Pages 361-362
Genetic Disorders of Bone and Connective Tissue (Skeletal Dysplasias)
Pages 363-365
Paget’s Disease of the Bone
Pages 369-375
Fibrous Dysplasia
Pages 377-380
Vanishing Bone Disease (Gorham-Stout Syndrome)
Pages 381-383
SAPHO Syndrome
Pages 385-386
Bone Marrow Oedema Syndrome
Pages 387-391
Complex Regional Pain Syndrome (CRPS, Sudeck’s Disease)
Pages 393-396
Ischaemic Bone Disease
Pages 397-405
Infections of Bone
Pages 407-411
Oral Bone Loss due to Periodontitis and Systemic Osteoporosis
Pages 413-415
Local Osteodysplasias
Pages 417-418
The Patient with “Extraskeletal Mineralisation”
Pages 421-422
Heterotopic Calcifications
Pages 423-425
Heterotopic Ossifications
Pages 427-428
Corticosteroid-Induced Osteoporosis
Pages 431-434
Transplantation Osteoporosis
Pages 435-436
Tumour-Therapy-Induced Osteoporosis
Pages 437-440
Drug-Induced Osteoporomalacia
Pages 441-441
Antiepileptic Drug-Related Osteopathy
Pages 443-444
Other Drugs Associated with Osteoporosis
Pages 445-445
The “Bone and Marrow” System
Pages 449-451
The Patient with “Myelogenous Osteopathy”
Pages 453-454
Anaemias and Bone Reactions
Pages 455-457
Leukaemias and Lymphomas of the Bone
Pages 459-460
Myelofibrosis/Osteomyelosclerosis Syndrome (MF/OMS)
Pages 461-462
Disorders of the Mononuclear Phagocyte System
Pages 463-466
Systemic Mastocytosis (SM)
Pages 467-469
Multiple Myeloma
Pages 471-480
Tumour-Induced Hypercalcaemia (TIH)
Pages 483-484
Tumour-Induced Bone Pain (TIBP)
Pages 485-486
Bone Metastases: Incidence and Development
Pages 487-492
Skeletal Metastases of Breast and Prostate Cancer
Pages 493-498
Other Tumours with Osteotropic Metastases
Pages 499-500
Primary Bone Tumours and Tumour-Like Lesions
Pages 501-519
The Normal Joint
Pages 523-525
Pathogenesis of Bone Disorders in Joint Diseases
Pages 527-528
Subchondral Cysts
Pages 529-529
Bone Reactions in Rheumatic Disorders
Pages 531-535
Degenerative, Metabolic and Neurogenic Joint Diseases
Pages 537-538
Infectious Joint Disorders
Pages 539-540
Peri-implant Bone Loss
Pages 541-545
Renal Osteodystrophy (ROD)
Pages 549-556
Haemodialysis-Associated Amyloidosis
Pages 557-560
Kidney Stones
Pages 561-562
Bone and Muscles
Pages 565-567
Bone and Skin
Pages 569-572
Bone and Fatty Tissue
Pages 573-574
Bone and Central Nervous System
Pages 575-578
Bone and Immune System
Pages 579-581
Bone and Teeth
Pages 583-584
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