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Biomarkers of the Tumor Microenvironment
Akslen, Watnick
Editore
Springer
Anno
2022
Pagine
593
ISBN
9783030989491
120,00 €

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This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Methodological advancements and practical applications, in terms of how biomarkers are studied and increasingly included in clinical trials and therapy protocols, are described and discussed.

 

Biomarkers of the Tumor Microenvironment is an educational resource for students and members of the cancer research community as a whole, especially for those using morphology analysis techniques and models focusing on the cross-talk between different cell types in tumors. The textbook provides a comprehensive overview of the microenvironment in various contexts from the perspectives of experienced and accomplished cancer researchers and clinicians.

  1. Front Matter

    Pages i-xvii

    PDF

  2. Basic Studies: Tumor Mechanisms and Tissue Biomarkers

    1. Front Matter

      Pages 1-1

      PDF

    2. The Role of the Tumor Microenvironment in Regulating Angiogenesis

      • Randolph S. Watnick

      Pages 3-15

    3. Tissue-Based Biomarkers of Tumor-Vascular Interactions

      • Lars A. Akslen

      Pages 17-30

    4. Molecular Phenotypes of Endothelial Cells in Malignant Tumors

      • Vladan Milosevic, Reidunn J. Edelmann, Johanna Hol Fosse, Arne Östman, Lars A. Akslen

      Pages 31-52

    5. Lymphatics in Malignant Tumors

      • Marek Wagner, Helge Wiig

      Pages 53-62

    6. Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support?

      • Cédric Zeltz, Roya Navab, Ning Lu, Marion Kusche-Gullberg, Ming-Sound Tsao, Donald Gullberg

      Pages 63-89

    7. Tissue Architecture in Cancer Initiation and Progression

      • Susan E. Leggett, Celeste M. Nelson

      Pages 91-107

    8. Tumor-Fibroblast Interactions in Carcinomas

      • Harsh Dongre, Daniela Elena Costea

      Pages 109-124

    9. Stromal PDGF Receptors; Impact on Prognosis and Response to Treatment

      • Carina Strell, Arne Östman

      Pages 125-138

    10. Inflammation and Cancer: Lipid Autacoid and Cytokine Biomarkers of the Tumor Microenvironment

      • Molly M. Gilligan, Bruce R. Zetter, Dipak Panigrahy

      Pages 139-158

    11. Role of Lymphocytes in Cancer Immunity and Immune Evasion Mechanisms

      • Kushi Kushekhar, Stalin Chellappa, Einar M. Aandahl, Kjetil Taskén

      Pages 159-182

    12. Drivers of EMT and Immune Evasion

      • Rolf A. Brekken, Katarzyna Wnuk-Lipinska

      Pages 183-194

    13. Inflammatory Biomarkers for Cancer

      • Alexandre Corthay, Guttorm Haraldsen

      Pages 195-205

    14. Tumor Infiltrating Lymphocytes in Breast Cancer: Implementation of a New Histopathological Biomarker

      • Giuseppe Floris, Glenn Broeckx, Asier Antoranz, Maxim De Schepper, Roberto Salgado, Christine Desmedt et al.

      Pages 207-243

    15. Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments

      • Divya Ramchandani, Tyler P. El Rayes, Dingcheng Gao, Nasser K. Altorki, Thomas R. Cox, Janine T. Erler et al.

      Pages 245-266

    16. The Role of Platelets in the Tumor Microenvironment

      • Qiuchen Guo, Harvey G. Roweth, Kelly E. Johnson, Sandra S. McAllister, Joseph E. Italiano Jr., Elisabeth M. Battinelli

      Pages 267-281

    17. Neurogenesis in the Tumor Microenvironment

      • Heidrun Vethe, Ole Vidhammer Bjørnstad, Manuel Carrasco, Lars A. Akslen

      Pages 283-293

    18. Neuropilins as Cancer Biomarkers: A Focus on Neuronal Origin and Specific Cell Functions

      • Dakshnapriya Balasubbramanian, Yao Gao, Diane R. Bielenberg

      Pages 295-306

    19. The Role of AXL Receptor Tyrosine Kinase in Cancer Cell Plasticity and Therapy Resistance

      • Maria L. Lotsberg, Kjersti T. Davidsen, Stacey D’Mello Peters, Gry S. Haaland, Austin Rayford, James B. Lorens et al.

      Pages 307-327

    20. Basic Studies: Tumor Mechanisms and Tissue Biomarkers

      1. Modeling the Tumor Microenvironment in Patient-Derived Xenografts: Challenges and Opportunities

        • Katrin Kleinmanns, Christiane Helgestad Gjerde, Anika Langer, Vibeke Fosse, Elvira García de Jalón, Calum Leitch et al.

        Pages 329-344

      2. Use of Imaging Mass Cytometry in Studies of the Tissue Microenvironment

        • Ida Herdlevær, Lucia Lisa Petrilli, Fatime Qosaj, Maria Vinci, Dario Bressan, Sonia Gavasso

        Pages 345-364

      3. Artificial Intelligence in Studies of Malignant Tumours

        • André Pedersen, Ingerid Reinertsen, Emiel A. M. Janssen, Marit Valla

        Pages 365-375

    21. Clinical Applications: Organ Related Studies of Biomarkers and Therapy

      1. Front Matter

        Pages 377-377

        PDF

      2. The Tumor and Its Microenvironment as Complementary Sources of Cancer Biomarkers

        • Roopali Roy, Emily Man, Rama Aldakhlallah, Emma Rashes, Marsha A. Moses

        Pages 379-400

      3. Gene Expression Signatures of the Tumor Microenvironment: Relation to Tumor Phenotypes and Progress in Breast Cancer

        • Elisabeth Wik, Lise M. Ingebriktsen, Lars A. Akslen

        Pages 401-424

      4. MR-Derived Biomarkers for Cancer Characterization

        • Eugene Kim, Morteza Esmaeili, Siver A. Moestue, Tone F. Bathen

        Pages 425-440

      5. The Influence of Tissue Architecture on Drug Response: Anticancer Drug Development in High-Dimensional Combinatorial Microenvironment Platforms

        • Tiina A. Jokela, Eric G. Carlson, Mark A. LaBarge

        Pages 441-452

      6. Models of Tumor Progression in Prostate Cancer

        • Waqas Azeem, Yaping Hua, Karl-Henning Kalland, Xisong Ke, Jan Roger Olsen, Anne Margrete Oyan et al.

        Pages 453-465

      7. Prostate Cancer Biomarkers: The Old and the New

        • Anette L. Magnussen, Ian G. Mills

        Pages 467-482

      8. The Role of the Microenvironment in Endometriosis: Parallels and Distinctions to Cancer

        • Michael S. Rogers

        Pages 483-496

      9. Tumor-Vascular Interactions in Non-Small Cell Lung Cancer

        • Maria Ramnefjell, Lars A. Akslen

        Pages 497-508

      10. Tumor–Host Interactions in Malignant Gliomas

        • Lina Leiss, Ercan Mutlu, Mohummad Aminur Rahman, Mette Hartmark Nilsen, Per Øyvind Enger

        Pages 509-518

      11. The Role of the Microenvironment in Tumor Promoting Stress Responses

        • Hanna Dillekås, Cornelia Schuster, Kjersti T. Davidsen, Oddbjørn Straume

        Pages 519-536

      12. Vascular Co-option in the Brain Tumor Microenvironment

        • Sarah Wang, Andrew C. Dudley

        Pages 537-547

      13. Biomarker Panels and Contemporary Practice in Clinical Trials of Personalized Medicine

        • Nina Louise Jebsen, Irini Ktoridou-Valen, Bjørn Tore Gjertsen

        Pages 549-562

      14. Cancer Biomarkers: A Long and Tortuous Journey

        • Wen Jing Sim, Kian Chung Lee, Jean Paul Thiery

        Pages 563-580

    22. Back Matter

      Pages 581-593

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