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The main goal of the second edition of this book is to update the content on the rapidly growing field of lymphoscintigraphy, a radionuclide-based imaging procedure that provides information on the functional status of the lymphatic system. Although the technique was originally introduced to identify the cause of peripheral edema (i.e., blockage of the venous or lymphatic circulation), more recent and widespread applications include radioguided biopsy of the sentinel lymph node in patients with solid cancers. This procedure is crucial for the adequate planning of oncologic surgery in a growing number of cancers, most notably breast cancer, cutaneous melanoma, head and neck cancers, penile cancer, and cervical cancer.
The book focuses on the latest advances in lymphoscintigraphy techniques, including both novel tracers recently approved for clinical use (especially in the field of sentinel lymph node mapping) and the expanding role of hybrid imaging with SPECT/CT – and in sentinel node detection using hybrid tracers (radiolabeled and fluorescent) for dual-signature guidance. Each chapter addresses the clinical application of lymphoscintigraphy in different anatomic areas or disease conditions. After an introductory section concerning the pathophysiology of the specific site/disease, the clinical relevance and impact of lymphoscintigraphy is demonstrated by a collection of richly illustrated teaching cases describing the lymphoscintigraphic patterns most commonly observed, as well as anatomic variants and technical pitfalls. Emphasis is placed on tomographic multimodality imaging.
The book gathers contributions by experts in nuclear oncology, who have revised their chapters by updating the didactic material and adding clinical cases. Regarding sentinel lymph node biopsy in particular, a major distinction of this text is the incorporation of the staging guidelines of the American Joint Committee on Cancer (8th edition) into the didactic material.
Anatomy and Physiology of Lymphatic Circulation: Application to Lymphatic Mapping
Pages 1-6
Nieweg, Omgo E. (et al.)
Pathophysiology of Lymphatic Circulation in Different Disease Conditions
Pages 7-20
Di Stefano, Rossella (et al.)
Methodological Aspects of Lymphatic Mapping: Radiopharmaceuticals, Multimodal Lymphatic Mapping Agents, Instrumentations
Pages 21-51
Bartoli, Francesco (et al.)
Methodological Aspects of Lymphoscintigraphy: Bicompartmental Versus Monocompartmental Radiocolloid Administration
Pages 53-78
Sollini, Martina (et al.)
Lymphoscintigraphy for the Differential Diagnosis of Peripheral Edema and Intracavitary Lymph Effusion
Pages 79-142
Sollini, Martina (et al.)
The Sentinel Lymph Node Concept
Pages 143-149
Nieweg, Omgo E.
General Concepts on Radioguided Sentinel Lymph Node Biopsy: Preoperative Imaging, Intraoperative Gamma Probe Guidance, Intraoperative Imaging, Multimodality Imaging
Pages 151-169
Orsini, Federica (et al.)
SPECT/CT Image Generation and Criteria for Sentinel Lymph Node Mapping
Pages 171-183
Valdés Olmos, Renato A. (et al.)
Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Lymph Node Biopsy in Breast Cancer
Pages 185-217
Pereira Arias-Bouda, Lenka M. (et al.)
Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Lymph Node Biopsy in Cutaneous Melanoma
Pages 219-259
Vidal-Sicart, Sergi (et al.)
Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Head and Neck Cancers
Pages 261-290
Valdés Olmos, Renato A. (et al.)
Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Non-small Cell Lung Cancer
Pages 291-298
Boni, Giuseppe (et al.)
Preoperative and Intraoperative Lymphatic Mapping for Sentinel Node Biopsy in Cancers of the Gastrointestinal Tract
Pages 299-314
Balagué, Carmen (et al.)
Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Cancers of the Female Reproductive System
Pages 315-330
Collarino, Angela (et al.)
Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Cancers of the Male Reproductive System
Pages 331-356
Vries, Hielke Martijn (et al.)
Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Lymph Node Biopsy in Kidney and Bladder Cancers
Pages 357-372
Bex, Axel (et al.)
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