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Physiology of Hemostasis
Pages 3-16
This book is an up-to-date reference on all aspects of anticoagulation and hemostasis in neurosurgery. After an opening section on basic principles and drug classes in current use, detailed consideration is given to coagulation issues relevant to all patients, not just neurosurgical ones. The coverage includes, for example, deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. A variety of important issues specific to neurosurgical practice are then addressed, and a summary of current guidelines and best practices is provided. By bringing together the latest knowledge from across the discipline, this book will serve as a sound basis for informed decision making in surgical practice. It will be of daily value for neurosurgeons and trainees worldwide and will also be of interest to emergency room physicians, surgeons in general, critical care physicians, neurologists, and hospital medicine specialists.
Physiology of Hemostasis
Pages 3-16
Laboratory Assessment of Physiologic and Pathologic Hemostasis
Pages 17-31
Current Anticoagulation Drugs and Mechanisms of Action
Pages 33-46
Reversal of Target-Specific Oral Anticoagulants
Pages 47-54
Overview, Measurement and Point-of-Care Testing of Platelet Function
Pages 55-64
Role of Antiplatelet Therapy in Neurosurgery: Efficacy and Safety Profiles
Pages 65-89
Congenital Coagulation Disorders
Pages 93-114
Acquired Coagulation Disorders
Pages 115-128
Regulation and Dysregulation of Fibrinolysis
Pages 129-137
Risks Associated with Administration of Allogeneic Blood Components
Pages 139-147
Common Coagulation Disorders That May Arise Intraoperatively: Specifically DIC
Pages 149-152
Evaluation and Management of Untoward Intraoperative Bleeding
Pages 153-165
Treatment of Disseminated Intravascular Coagulation (DIC)
Pages 167-182
Heparin-Induced Thrombocytopenia (HIT)
Pages 183-194
Anticoagulation in Cardiovascular Diseases
Pages 195-214
Workup and Treatment of Pulmonary Embolus
Pages 215-224
Classes of Drugs and Blood Products for Acute Reversal of Anticoagulant Effect
Pages 227-242
Rescue Strategies to Facilitate Emergency Neurosurgery in Patients on Antiplatelet or Anticoagulant Agents
Pages 243-256
Considerations for Coagulation in the Multi‐trauma Patient
Pages 257-267
Cerebral Venous Sinus Thrombosis
Pages 269-284
Coagulation Studies in Preoperative Neurosurgery Patients
Pages 285-296
Safe Strategies for Gradual Suspension and Reinstitution of Anticoagulation to Permit Elective Surgery
Pages 297-307
Spontaneous Intracerebral Hemorrhage Due to Coagulation Disorders
Pages 309-316
Prophylactic Screening for Venous Thromboembolism in Neurosurgical Patients
Pages 317-325
Venous Thromboembolism Prophylaxis in Neurosurgery
Pages 327-342
Can Patients with Known Intracranial and Intraspinal Vascular Lesions Be Anticoagulated?
Pages 343-361
Intrathecal Access and Devices in Patients on Antiplatelet or Anticoagulant Therapy
Pages 363-368
Is It Safe to Shunt Anticoagulated NPH Patients?
Pages 369-380
Surgical Hemostasis in the Era of Anticoagulation: Guidelines and Recommendations Summary
Pages 381-392
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