Titolo: Antibody Therapy

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Antibody Therapy

Substitution – Immunomodulation – Monoclonal Immunotherapy

Editore

Springer

Anno

2018

Pagine

363

ISBN

9783319680378

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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This practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice). The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other diseases. Basic aspects of IgG concentrates, including methods of production, safety, currently available products, and mechanisms of action, are then discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally, the transition from polyclonal to monoclonal antibody (mAb) treatment is addressed in detail, covering mAb development, methods, mechanisms of action, adverse effects, and more. Particular attention is paid to the example of anti-CD20 (B-cell) antibody.

The Clinical Translation of Intravenous Immunoglobulin from Substitution to Immunomodulation

Imbach, Paul

Pages 1-11
From Immune Substitution to Immuno-modulation

Wahn, Volker

Pages 15-22
Manual of Primary and Secondary Immunodeficiencies

Imbach, Paul (et al.)

Pages 23-33
Manual of Intravenous and Subcutaneous IgG Indications in Autoimmune Diseases

Imbach, Paul

Pages 35-60
Anti-D: A Type of IVIg

Khan, Ramsha, HBSc (et al.)

Pages 61-71

Mechanisms of Action and Immunomodulation by IVIg

Lazarus, Alan H., PhD

Pages 73-83
Immunomodulatory Drugs and Monoclonal Antibodies

Liebman, Howard A., MA, MD

Pages 85-100
Use of Intravenous Immunoglobulin in Neurology

Dalakas, Marinos C., MD, FAAN

Pages 101-109
Use of Intravenous Immunoglobulin in Dermatology

Hoffmann, Jochen H. O. (et al.)

Pages 111-118
Historical Aspects of Polyclonal IgG Preparations

Wahn, Volker (et al.)

Pages 121-132
Basics of Immunoglobulins as Effector Molecules and Drugs

Vassilev, Tchavdar L. (et al.)

Pages 133-150
Essentials of the Production of Safe and Efficacious State-of-the-Art Polyclonal IgG Concentrates

Späth, Peter J.

Pages 151-173
Current IgG Products and Future Perspectives

Späth, Peter J.

Pages 175-202
Updates in Immune Thrombocytopenia: Terminology, Immunomodulation and Platelet Stimulation, and Clinical Guidelines and Management

Neunert, Cindy, MD, MSCS

Pages 205-212
Health-Related Quality of Life in Patients with Immune Thrombocytopenia

Klaassen, Robert J., MD (et al.)

Pages 213-222
ITP in Childhood: Predictors of Disease Duration

Bennett, Carolyn M., MD, MSc

Pages 223-239
Immune Functions of Platelets

Kapur, Rick (et al.)

Pages 241-259
Thrombopoietin Receptor Agonists: Characteristics, Adverse Effects, and Indications

Despotovic, Jenny, DO, MS (et al.)

Pages 261-276
Registries in Immune Thrombocytopenia: The History of the Intercontinental Cooperative ITP Study Group

Kühne, Thomas, MD

Pages 277-287
Therapeutic Monoclonal Antibodies as Immunomodulators and Anti-Cancer Agents: Development, Evidence of Efficacy, Mechanisms of Actions, Adverse Effects

Niehues, Tim

Pages 291-341
Monoclonal Anti-CD20 (B-Cell) Antibody and Autoimmune Diseases

Godeau, Bertrand, MD

Pages 343-363