Front Matter

Pages i-ix

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Precision Medicine

1. Front Matter

   Pages 1-1

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2. The Role of Transcriptomics in Redefining Critical Illness

   • T. M. Pelaia, M. Shojaei, A. S. McLean

   Pages 3-14

3. Metagenomic Sequencing in the ICU for Precision Diagnosis of Critical Infectious Illnesses

   • L. P. A. Neyton, C. R. Langelier, C. S. Calfee

   Pages 15-25

4. Risk Stratification and Precision Medicine: Is It Feasible for Severe Infections?

   • E. J. Giamarellos-Bourboulis, M. Mouktaroudi, M. G. Netea

   Pages 27-37

5. Interrogating the Sepsis Host Immune Response Using Cytomics

   • R. B. Lindell, N. J. Meyer

   Pages 39-48

6. Precision Medicine in Septic Shock

   • L. Chiscano-Camón, J. C. Ruiz-Rodriguez, R. Ferrer

   Pages 49-68

Sepsis Biomarkers and Organ Dysfunction Scores

1. Front Matter

   Pages 69-69

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2. Host Response Biomarkers for Sepsis in the Emergency Room

   • O. Turgman, M. Schinkel, W. J. Wiersinga

   Pages 71-81

3. Repetitive Assessment of Biomarker Combinations as a New Paradigm to Detect Sepsis Early

   • P. Eggimann, Y. -A. Que, F. Ventura

   Pages 83-92

4. Organ Dysfunction Scores in the Adult ICU

   • A. Reintam Blaser, K. F. Bachmann, Y. M. Arabi

   Pages 93-108

ARDS

1. Front Matter

   Pages 109-109

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2. Ex Vivo Lung Perfusion Models to Explore the Pathobiology of ARDS

   • A. Abdalla, K. Dhaliwal, M. Shankar-Hari

   Pages 111-119

3. Interpretation of Lung Perfusion in ARDS

   • L. Ball, F. Marchese, P. Pelosi

   Pages 121-138

4. A Structured Diagnostic Algorithm for Patients with ARDS

   • L. D. J. Bos, H. -J. de Grooth, P. R. Tuinman

   Pages 139-149

5. Hemodynamic Implications of Prone Positioning in Patients with ARDS

   • C. Lai, X. Monnet, J. -L. Teboul

   Pages 151-162

Ventilatory Support

1. Front Matter

   Pages 163-163

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2. Update on the Management of Acute Respiratory Failure Using Non-invasive Ventilation and Pulse Oximetry

   • T. Abe, T. Takagi, T. Fujii

   Pages 165-175

3. Managing the Physiologically Difficult Airway in Critically Ill Adults

   • C. S. Jabaley

   Pages 177-189

4. Dyspnea in Patients Receiving Invasive Mechanical Ventilation

   • M. Decavèle, C. Bureau, A. Demoule

   Pages 191-205

5. Ventilatory Support

   1. The Potential Risks of Pressure Support Ventilation

      • A. Proklou, V. Karageorgos, K. Vaporidi

      Pages 207-220

   2. Advancing Sedation Strategies to Improve Clinical Outcomes in Ventilated Critically Ill Patients

      • Y. Shehabi, W. Al-Bassam, D. Antognini

      Pages 221-235

6. Extracorporeal Support

   1. Front Matter

      Pages 237-237

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   2. Setting and Monitoring of Mechanical Ventilation During Venovenous ECMO

      • B. Assouline, A. Combes, M. Schmidt

      Pages 239-252

   3. Early Mobilization in Patients Receiving ECMO for Respiratory Failure

      • K. E. Melville, D. Brodie, D. Abrams

      Pages 253-261

   4. Physiological Adaptations During Weaning from Venovenous ECMO

      • P. D. Collins, L. Giosa, L. Camporota

      Pages 263-285

   5. Novel Strategies to Enhance the Efficiency of Extracorporeal CO2 Removal

      • G. Florio, A. Zanella, G. Grasselli

      Pages 287-299

   6. Extracorporeal Cardiopulmonary Resuscitation for Out-Of-Hospital Cardiac Arrest: A Systematic Approach

      • D. Rob, J. Bělohlávek

      Pages 301-310

   7. Temporary and Durable Mechanical Circulatory Support in the ICU

      • A. Pinsino, M. N. Gong, M. Rahmanian

      Pages 311-323

7. Fluids and Transfusion

   1. Front Matter

      Pages 325-325

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   2. Venous Congestion: Why Examine the Abdomen with Ultrasound in Critically Ill Patients?

      • A. Y. Denault, P. Rola, W. Beaubien-Souligny

      Pages 327-338

   3. The Most Important Questions in the Current Practice of Transfusion of Critically Bleeding Patients

      • A. W. Flint, J. Winearls, M. C. Reade

      Pages 339-353

8. Acute Renal Failure

   1. Front Matter

      Pages 355-355

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   2. Fluid Management and Acute Kidney Injury

      • N. Lumlertgul, N. Z. Nordin, M. Ostermann

      Pages 357-375

   3. Cardiorenal Syndrome 1: What’s in a Name?

      • H. A. I. Schaubroeck, W. Vandenberghe, E. A. J. Hoste

      Pages 377-388

9. The Microcirculation and Metabolism

   1. Front Matter

      Pages 389-389

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   2. Update on the Microcirculatory Assessment of the Critically Ill Patient

      • S. H. Kuo, B. Ergin, C. Ince

      Pages 391-400

   3. Intracellular Measurements of Micronutrients in the Critically Ill

      • A. M. E. de Man, F. A. L. van der Horst, X. Forceville

      Pages 401-413

   4. Optimal Glycemic Targets in Critically Ill Patients with Diabetes

      • A. P. Poole, M. Horowitz, A. Deane

      Pages 415-428

10. A Look Back at COVID-19

    1. Front Matter

       Pages 429-429

    2. A Look Back at COVID-19

       1. Hydroxychloroquine: Time for Reappraisal of Its Effect in COVID-19 Patients

          • V. Cés de Souza Dantas, J. P. Cidade, P. Póvoa

          Pages 431-439

       2. Blood Purification in COVID-19 in the Absence of Acute Kidney Injury

          • P. M. Honoré, S. Blackman, E. Perriens

          Pages 441-449

    3. Neurologic Considerations

       1. Front Matter

          Pages 451-451

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       2. Epidemiology, Outcomes, and Costs of Pediatric Traumatic Brain Injury Treated in the ICU

          • E. Mikkonen, R. Raj, M. B. Skrifvars

          Pages 453-466

       3. Quality Improvement in the Determination of Death by Neurologic Criteria Around the World

          • A. Lewis, M. P. Kirschen, R. Badenes

          Pages 467-485

    4. Obstetric Issues

       1. Front Matter

          Pages 487-487

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       2. COVID-19 ARDS in Pregnancy: Implications for the Non-COVID Era

          • M. Di Nardo, M. C. Casadio, V. M. Ranieri

          Pages 489-501

       3. Amniotic Fluid Embolism

          • E. LaFond, J. Bakker

          Pages 503-509

    5. Pre- and Post-Intensive Care

       1. Front Matter

          Pages 511-511

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       2. Remote Telehealth Aid During Humanitarian Crisis

          • J. A. Yelon, S. Subramanian, L. J. Kaplan

          Pages 513-522

       3. Boarding in the Emergency Department: Challenges and Success Strategies to Mitigate the Current Crisis

          • H. Bailey

          Pages 523-532

       4. Post-Intensive Care Syndrome Revisited in Light of the COVID-19 Pandemic

          • K. Kotfis, K. Lechowicz, W. Dąbrowski

          Pages 533-545

    6. Ethical Issues

       1. Front Matter

          Pages 547-547

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       2. Rethinking the Role of Palliative Care in the ICU

          • M. S. F. Chong, V. Metaxa

          Pages 549-559

    7. Back Matter

       Pages 561-566