Contents

1 Changing Demographics of the Aging Population
with Heart Failure and Implications for Therapy...................... 1
Bodh I. Jugdutt
2 Biology of Aging and Implications
for Heart Failure Therapy and Prevention................................. 15
Bodh I. Jugdutt
3 Hypertension and Prevention of Diastolic
Heart Failure in the Aging Population......................................... 35
Wilbert S. Aronow, Maciej Banach, and Ali Ahmed
4 Aging and Optimal Therapy of Systolic
Heart Failure in the Elderly.......................................................... 47
Nakul Chander Sharma and Bodh I. Jugdutt
5 Atrial Fibrillation and Heart Failure
in the Aging Population................................................................. 65
Pedram Kazemian and Bodh I. Jugdutt
6 Optimizing Therapy of Heart Failure in the Aging
Population with Monitoring in Clinics......................................... 85
John R. Dimitry and Justin A. Ezekowitz
7 Cardiac Alterations in Aging, Hypertension,
and Diastolic Heart Failure........................................................... 95
Edith Pituskin and D. Ian Paterson
8 Polypharmacy and Adverse Drug Reactions
in the Aging Population with Heart Failure................................ 107
Michael W. Rich and William J. Nienaber
9 Age-Related Changes in Vascular Biology
and Implications for Heart Failure Therapy
in the Aging Population................................................................ 117
Michael Sean McMurtry
10 Biomarkers and Optimal Management
of Heart Failure in the Aging Population.................................... 135
Hanna K. Gaggin and James L. Januzzi Jr.

11 Benefits of Exercise in the Elderly................................................ 147
Ezra A. Amsterdam and C. Tissa Kappagoda
12 The RAAS in Heart Failure: An Update on Clinical
Trials and Opportunities for Therapy......................................... 165
C.Tissa Kappagoda and Ezra A. Amsterdam
13 Aging and Diastolic Dysfunction: The Interplay
of Inflammation and Extracellular Matrix Regulation............. 183
Peter Moritz Becher, Dirk Westermann,
and Carsten Tschöpe
14 Reperfusion and Vasodilator Therapy
in Elderly Patients with STEMI and Heart Failure:
Improving Outcomes..................................................................... 199
Bodh I. Jugdutt, Anwar Jelani, Seraj Abualnaja,
Nakul Chander Sharma, and Joseph Szeman Wong
15 Erythropoietin Therapy for Heart Failure.................................. 221
Margarita Borovka and Mathew S. Maurer
16 Role of Resistin in Heart Failure in the Elderly.......................... 243
Yasuchika Takeishi
17 Role of Coronary Artery Calcium in Cardiovascular
Risk Stratification and Management
in the Aging Population................................................................. 249
Craig R. Butler and Paolo Raggi
18 Aging and Remodeling of the RAS
and RAAS and Related Pathways:
Implications for Heart Failure Therapy...................................... 259
Bodh I. Jugdutt
19 Aging and Right Ventricular Failure from Pulmonary
Hypertension: Effect of Right Ventricular
and Pulmonary Artery Remodeling............................................. 291
Joseph Szeman Wong and Bodh I. Jugdutt
20 Biomarkers of Cardiovascular Aging........................................... 305
Nirankar S. Neki, Paramjit S. Tappia,
and Naranjan S. Dhalla
21 Changes in the Heart That Accompany
Advancing Age: Humans to Molecules........................................ 319
Edward G. Lakatta, Harold A. Spurgeon,
and Andrzej M. Janczewski
22 Aging-Related Changes in Cell Death
and Cell Survival Pathways and Implications
for Heart Failure Therapy............................................................. 339
Guido R.Y. De Meyer, Dorien M. Schrijvers,
and Wim Martinet

23 Aging-Related Changes in Telomeres and Telomerases
and Implications for Heart Failure Therapy............................... 351
Pim van der Harst and Dirk J. van Veldhuisen
24 Aging-Associated Alterations in Myocardial Inflammation
and Fibrosis: Pathophysiological Perspectives
and Clinical Implications.............................................................. 361
Arti V. Shinde and Nikolaos G. Frangogiannis
25 Aging-Related Changes in Extracellular Matrix:
Implications for Ventricular Remodeling
Following Myocardial Infarction.................................................. 377
Nguyen T. Nguyen, Andriy Yabluchanskiy,
Lisandra E. de Castro Brás, Yu-Fang Jin, and Merry L. Lindsey
26 Calcium-Handling Defects and Changes
in Cardiac Function in the Aging Heart...................................... 391
Adriana Adameova, Nirankar S. Neki, Paramjit S. Tappia,
and Naranjan S. Dhalla
27 Integrins: Implications for Aging
in Heart Failure Therapy.............................................................. 401
Laura L. Daniel, William L. Joyner, Mahipal Singh,
and Krishna Singh
28 Adipokines as Novel Biomarkers in Aging
and Heart Failure........................................................................... 411
Ken Shinmura
29 Aging-Related Changes in Cellular and Molecular
Mechanisms of Postinfarction Remodeling:
Implications for Heart Failure Therapy...................................... 427
Henry Han-Jen Shih and Andrew J. Boyle
30 Aging-Related Changes in Mitochondrial Function
and Implication for Heart Failure Therapy................................ 439
Satoaki Matoba, Atsushi Hoshino, and Hiroaki Matsubara
31 Regulation of SERCA Via Oxidative Modifications:
Implications for the Pathophysiology of Diastolic
Dysfunction in the Aging Heart.................................................... 449
Fuzhong Qin, Richard A. Cohen, and Wilson S. Colucci
32 SMP30 and Aging-Related Cardiac Remodeling
and Heart Failure........................................................................... 457
Satoshi Suzuki and Yasuchika Takeishi
Index........................................................................................................ 465