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Libreria medica internazionale
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Advances in Geroscience
Sierra, Kohanski
Editore
Springer
Anno
2016
Pagine
622
ISBN
9783319232454
190,00 €
I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.
  • Provides a comprehensive overview of the new discipline, geroscience
  • Examines mechanisms and consequences of aging as the main risk factor for most chronic diseases
  • Provides links between aging biology and age-related diseases
  • Provides specific coverage on a wide range of chronic diseases, from both basic and clinical perspectives

This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’

The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV.  It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.

Table of contents (19 chapters)

 
  • The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?

    Austad, Steven N.

    Pages 1-36

  • Etiological Role of Aging in Chronic Diseases: From Epidemiological Evidence to the New Geroscience

    Fried, Linda P. (et al.)

    Pages 37-51

  • The Impact of Aging on Cancer Progression and Treatment

    He, Shenghui (et al.)

    Pages 53-83

  • The Impact of Cancer Treatments on Aging

    Lee, Changhan (et al.)

    Pages 85-119

  • Cardiovascular Disease and Aging

    Chiao, Ying Ann (et al.)

    Pages 121-160

  • The Impact of Aging on Ischemic Stroke

    Sohrabji, Farida

    Pages 161-196

  • The Role of Aging in Alzheimer’s Disease

    Kerchner, Geoffrey A. (et al.)

    Pages 197-227

  • Parkinson’s Disease and Aging

    Andersen, Julie K. (et al.)

    Pages 229-255

  • Aging and the Bone-Muscle Interface

    Melov, Simon (et al.)

    Pages 257-275

  • Osteoporosis and Mechanisms of Skeletal Aging

    Glowacki, Julie (et al.)

    Pages 277-307

  • Osteoarthritis in the Elderly

    Loeser, Richard F. (et al.)

    Pages 309-353

  • Diabetes and Aging

    Musi, Nicolas (et al.)

    Pages 355-376

  • Renal Aging and Transplantation

    Higgins, John P. (et al.)

    Pages 377-396

  • Asthma and Aging

    Hanania, Nicola A. (et al.)

    Pages 397-428

  • Aging in COPD and Idiopathic Pulmonary Fibrosis

    Sanchez, Cecilia G.

    Pages 429-470

  • Age-Related Macular Degeneration and Vision Impairment

    Wright, Charles (et al.)

    Pages 471-507

  • HIV and Aging: Parallels and Synergistic Mechanisms Leading to Premature Disease and Functional Decline

    Hearps, Anna (et al.)

    Pages 509-550

  • Pain in the Elderly

    Fillingim, Roger B. (et al.)

    Pages 551-592

  • The Way Forward: Translation

    Kirkland, James L. (et al.)

    Pages 593-622

 

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