Titolo: Acute Promyelocytic Leukemia

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Acute Promyelocytic Leukemia

A Clinical Guide

Editore

Springer

Anno

2018

Pagine

274

ISBN

9783319642567

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.

Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.

History of Acute Promyelocytic Leukemia

Degos, Laurent, M.D., Ph.D.

Pages 1-16
Molecular Targets of Treatment in APL

Rahmé, Ramy, M.D. (et al.)

Pages 17-27
The Leukemic Stem Cell

Vlachou, Thalia, Ph.D. (et al.)

Pages 29-40
Molecular Genetics of APL

Mendez, Lourdes, M.D., Ph.D. (et al.)

Pages 41-53
APL Coagulopathy

Falanga, Anna, M.D. (et al.)

Pages 55-70

Early Death in APL

Lehmann, Sören, M.D., Ph.D.

Pages 71-86
Prognostic Factors in APL

Serna, Javier, M.D. (et al.)

Pages 87-98
First-Line Therapy for APL: Chemotherapy-Based Approach

Goldberg, Aaron D., M.D., Ph.D. (et al.)

Pages 99-112
First-Line Therapy: ATRA-ATO/Reduced Chemotherapy Approach

Iland, Harry, M.B.B.S., F.R.A.C.P., F.R.C.P.A.

Pages 113-132
Cure of APL Without Chemotherapy

Percival, Mary-Elizabeth M., M.D. (et al.)

Pages 133-151
Minimal Residual Disease in APL

Cicconi, Laura, M.D. (et al.)

Pages 153-161
Treatment of Refractory and Relapsed APL

Lengfelder, Eva, M.D.

Pages 163-170
Hematopoietic Stem Cell Transplantation in APL

Sanz, Jaime, M.D. (et al.)

Pages 171-177
APL in Children

Kutny, Matthew A., M.D. (et al.)

Pages 179-195
Management of APL in the Elderly

Rahmé, Ramy, M.D. (et al.)

Pages 197-201
Special Situations in APL

Breccia, Massimo, M.D., Ph.D. (et al.)

Pages 203-210
APL in Developing Countries: A Chemotherapy-Based Approach

Araújo Koury, Luisa Corrêa, M.D. (et al.)

Pages 211-216
APL in Developing Countries: ATO-Based Approach

Mathews, Vikram, M.B.B.S., M.D., D.M.

Pages 217-229
Therapy-Related Acute Promyelocytic Leukemia

Pettit, Kristen, M.D. (et al.)

Pages 231-242
Rare Acute Leukemia Variants Involving Retinoic Acid Receptor Genes

Cicconi, Laura, M.D. (et al.)

Pages 243-255
Management of Treatment-Related Complications in APL

Annibali, Ombretta, M.D., Ph.D. (et al.)

Pages 257-267