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This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis.Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.
Acute Kidney Injury: Definition and Epidemiology
Pages 3-20
Horino, Taro
Causes of AKI (Prerenal, Intrarenal, Postrenal)
Pages 21-32
Ikai, Hiroki (et al.)
Pathophysiology of AKI
Pages 33-45
Yasuda, Hideo
Diagnosis of AKI: Clinical Assessment, Novel Biomarkers, History, and Perspectives
Pages 47-58
Mori, Kiyoshi (et al.)
Risk Factors for AKI Development in Surgery (Non-cardiac Surgery)
Pages 59-67
Wakino, Shu
Risk Factors for AKI Development in Acute Decompensated Heart Failure
Pages 69-83
Joki, Nobuhiko (et al.)
Contrast-Induced Acute Kidney Injury
Pages 85-98
Fujigaki, Yoshihide
Antibiotics- and Immunosuppressants-Related AKI
Pages 99-110
Furuichi, Kengo (et al.)
AKI in Setting of Cancer
Pages 111-124
Kitai, Yuichiro (et al.)
Community- and Hospital-Acquired Acute Kidney Injury
Pages 125-144
Peerapornratana, Sadudee (et al.)
Complication of Homeostasis (Electrolytes and Acid-Base)
Pages 147-162
Uehara, Atsuko (et al.)
Volume Overload and Pulmonary Complications
Pages 163-179
Tada, Masashi (et al.)
Prophylaxis and Management of Acute Kidney Injury
Pages 183-200
Komatsu, Yasuhiro
Postrenal AKI
Pages 201-213
Nagaya, Naoya (et al.)
Acute Kidney Injury in Intensive Care Medicine
Pages 215-224
Yoshimoto, Kohei (et al.)
Nondialytic Supportive Management of AKI
Pages 225-237
Yamada, Hiroyuki
Renal Replacement Therapy in AKI
Pages 239-254
Negi, Shigeo (et al.)
Short-Term and Long-Term Outcomes of AKI Patients
Pages 255-265
Furuichi, Kengo (et al.)
Management of Pediatric AKI
Pages 267-279
Kamei, Koichi
AKI-to-CKD Transition
Pages 283-296
Kaimori, Jun-Ya
Role of the Nervous System in Acute Kidney Injury
Pages 297-316
Uni, Rie (et al.)
AKI and Immune System
Pages 317-332
Jo, Sang Kyung (et al.)
Acute Kidney Injury and Cytokines
Pages 333-351
Furuhashi, Kazuhiro (et al.)
iPS Cell and Renal Regenerative Medicine
Pages 355-370
Araoka, Toshikazu (et al.)
Kidney Development and Injury: A Road to Regeneration
Pages 371-381
De, Shankhajit (et al.)
Xenotransplanted Embryonic Kidney
Pages 383-396
Saito, Yatsumu (et al.)
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