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Molecular Pathology of Liver Diseases

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Autore: Monga
Editore: Springer
Anno: 2011
Pagine: 931
ISBN: 9781441971067
Prezzo: 200,00€
I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.
  • One-stop reference for comprehending the molecular mechanisms of hepatic pathobiology and information
  • Visual approach includes an abundance of tables and diagrams
Molecular Pathology of Liver Diseases integrates the traditional knowledge of physiological and pathological processes in the liver with a balanced emphasis on fundamental concepts; timely advances in cellular and molecular mechanisms; and applied pathology. The textbook is organized into several sections, each of which includes an array of chapters that progressively and cohesively elaborate on pertinent liver biology and pathology. The first three sections discuss the cellular composition of the liver along with their specialized functions, and further dissect the molecular basis of the cellular processes that are so unique to the liver. The next section examines the mechanisms that are commonly implicated in the cellular and molecular basis of several hepatic pathologies, followed eventually by a section each on a multitude of non-neoplastic and neoplastic diseases of the liver. Molecular Pathology of Liver Diseases is a comprehensive reference on liver pathobiology for basic, translational and clinical researchers and physicians The format of the volume will serve as a ready reference to relevant topics in the liver, thus providing a practical disease-based integrative resource on the molecular pathology of liver disease. Satdarshan (Paul) Singh Monga, MD is Director: Division of Experimental Pathology and Associate Professor of Pathology and Medicine, University of Pittsburgh, Pittsburgh, PA

xi
Contents
Part I Liver Cells and Functions.................................................................................. 1
1 Gross and Cellular Anatomy of the Liver.............................................................. 3
Allan Tsung and David A. Geller
2 Liver Zonation........................................................................................................... 7
Sabine Colnot and Christine Perret
3 Hepatocytes................................................................................................................ 17
Alejandro Soto-Gutierrez, Nalu Navarro-Alvarez, and Naoya Kobayashi
4 Biliary Epithelial Cells.............................................................................................. 27
Yoshiaki Mizuguchi, Susan Specht, Kumiko Isse, John G. Lunz III,
and Anthony J. Demetris
5 Stellate Cells.............................................................................................................. 53
Chandrashekhar R. Gandhi
6 Kupffer Cells............................................................................................................. 81
Chandrashekhar R. Gandhi
7 Sinusoidal Endothelial Cells.................................................................................... 97
Donna Beer Stolz
8 Hepatic Carbohydrate Metabolism......................................................................... 109
Dirk Raddatz and Giuliano Ramadori
9 Hepatic Protein Metabolism.................................................................................... 125
Wouter H. Lamers, Theodorus B.M. Hakvoort, and Eleonore S. Köhler
10 Hepatic Lipid Metabolism........................................................................................ 133
Jiansheng Huang, Jayme Borensztajn, and Janardan K. Reddy
11 Detoxification Functions of the Liver...................................................................... 147
Udayan Apte and Partha Krishnamurthy
12 Bile Acid Metabolism................................................................................................ 165
John Y.L. Chiang
Part II Molecular Basis of Liver Development, Growth, and Senescence................ 181
13 Liver Development.................................................................................................... 183
Klaus H. Kaestner
xii Contents
14 Transcriptional Control of Hepatocyte Differentiation......................................... 193
Joseph Locker
15 Bile Duct Development and Biliary Differentiation............................................... 213
Frederic P. Lemaigre
16 Hepatic Progenitors in Development and Transplantation................................... 225
David A. Shafritz, Michael Oertel, and Mariana D. Dabeva
17 Adult Liver Stem Cells............................................................................................. 243
D. Hunter Best and William B. Coleman
18 Liver Regeneration................................................................................................... 261
George K. Michalopoulos
19 Senescent Liver.......................................................................................................... 279
Nikolai A. Timchenko
20 Signaling Pathways in the Liver.............................................................................. 291
Abigale Lade and Satdarshan Pal Singh Monga
Part III Applied Liver Biology...................................................................................... 307
21 Hepatocyte Transplantation..................................................................................... 309
Mirela-Patricia Sirbu-Boeti, Kyle Soltys, Alejandro Soto-Gutierrez,
and Ira J. Fox
22 Hepatic Tissue Engineering..................................................................................... 321
Jing Shan, Kelly R. Stevens, Kartik Trehan, Gregory H. Underhill,
Alice A. Chen, and Sangeeta N. Bhatia
23 Hepatic Gene Therapy.............................................................................................. 343
Hiroyuki Nakai
Part IV Basic Principles of Hepatobiliary Pathology................................................ 371
24 Liver Cell Death........................................................................................................ 373
Harmeet Malhi and Gregory J. Gores
25 Macroautophagy....................................................................................................... 389
Ying-Hong Shi, Jia Fan, Chih Wen Lin, Wen-Xing Ding,
and Xiao-Ming Yin
26 Hepatic Ischemia/Reperfusion Injury..................................................................... 397
Callisia N. Clarke, Amit D. Tevar, and Alex B. Lentsch
27 Inflammation and Liver Injury............................................................................... 411
Pranoti Mandrekar and Gyongyi Szabo
28 Oxidative Stress and Liver Injury........................................................................... 427
Francisco Javier Cubero and Christian Trautwein
29 Fatty Liver................................................................................................................. 437
Jaideep Behari
Contents xiii
30 Hepatic Fibrosis and Cirrhosis................................................................................ 449
Rebecca G. Wells
31 Biliary Cirrhosis........................................................................................................ 467
Jonathan A. Dranoff
32 Cholestasis................................................................................................................. 475
Michael H. Trauner
33 Portal Hypertension.................................................................................................. 485
Sumit K. Singla and Vijay H. Shah
Part V Molecular Pathobiology of Non-Neoplastic Hepatobiliary Disorders.......... 497
34 Nonalcoholic Fatty Liver Disease............................................................................ 499
Onpan Cheung and Arun J. Sanyal
35 Alcoholic Liver Disease............................................................................................. 511
Samuel W. French
36 Viral Hepatitis A....................................................................................................... 527
Shiv K. Sarin and Manoj Kumar
37 Viral Hepatitis B ....................................................................................................... 553
Mark A. Feitelson, Alla Arzumanyan, Helena M.G.P.V. Reis,
Marcia M. Clayton, Bill S. Sun, and Zhaorui Lian
38 Viral Hepatitis C....................................................................................................... 569
Jiaren Sun, Gaurav Chaturvedi, and Steven A. Weinman
39 Viral Hepatitis D....................................................................................................... 589
John M. Taylor
40 Viral Hepatitis E........................................................................................................ 597
Shiv K. Sarin and Manoj Kumar
41 Autoimmune Hepatitis.............................................................................................. 623
Albert J. Czaja
42 Toxicant-Induced Liver Injury................................................................................ 641
Hartmut Jaeschke
43 Wilson’s Disease........................................................................................................ 655
Michael L. Schilsky and Kisha Mitchell
44 Hemochromatosis...................................................................................................... 665
James E. Nelson, Debbie Trinder, and Kris V. Kowdley
45 Glycogen Storage Diseases....................................................................................... 677
Mingyi Chen
46 α1-Antitrypsin Deficiency......................................................................................... 683
David H. Perlmutter
xiv Contents
47 Hepatic Artery Diseases........................................................................................... 701
Ton Lisman and Robert J. Porte
48 Hepatic Venous Outflow Obstruction..................................................................... 709
Yusuf Bayraktar
49 Primary Biliary Cirrhosis........................................................................................ 725
Carlo Selmi and M. Eric Gershwin
50 Primary Sclerosing Cholangitis............................................................................... 741
Marina G. Silveira and Keith D. Lindor
51 Biliary Atresia........................................................................................................... 753
Jorge A. Bezerra
Part VI Molecular Pathobiology of Neoplastic Hepatobiliary Diseases................... 767
52 Benign Liver Tumors................................................................................................ 769
Jessica Zucman-Rossi
53 Hepatoblastoma......................................................................................................... 777
Marie Annick Buendia and Monique Fabre
54 Hepatocyte Growth, Proliferation and Experimental Carcinogenesis................. 791
Giovanna Maria Ledda-Columbano and Amedeo Columbano
55 Stem Cells and Liver Cancer................................................................................... 815
Stewart Sell
56 Primary Hepatocellular Carcinoma........................................................................ 831
Jean-François Dufour and Caroline Hora
57 Fibrolamellar Hepatocellular Carcinoma.............................................................. 849
Sanjay Kakar
58 Biology of Metastatic Liver Tumors........................................................................ 859
Alan Wells, Yvonne Chao, and Qian Wu
59 Cholangiocarcinoma................................................................................................. 867
Gianfranco D. Alpini, Heather L. Francis, Marco Marzioni,
Domenico Alvaro, Eugenio Gaudio, Ivano Lorenzini,
Antonio Benedetti, and Giammarco Fava
60 Neoplasms of Extrahepatic Bile Duct...................................................................... 881
Nora Katabi, Juan Carlos Roa, and N. Volkan Adsay
61 Neoplasms of the Gallbladder.................................................................................. 891
Juan Carlos Roa, Nora Katabi, and N. Volkan Adsay
62 Current and Future Methods for Diagnosis of Neoplastic Liver Disease............ 907
Arief A. Suriawinata, Michael Tsapakos, and Gregory J. Tsongalis
Index................................................................................................................................... 917
 

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