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Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma

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Autore: Murphy
Editore: Springer
Anno: 2012
Pagine: 322
ISBN: 9781607614326
Prezzo: 160,00€
I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.
  • Reviews major advances in molecular methods, using an evidence-based perspective
  • Explores powerful tools for determining treatment decisions
  • An essential resource for oncologists, dermatologists, pathologists, and melanoma researchers

This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.

 

ix
1 Introduction to Diagnostic and Prognostic Biomarkers
and Therapeutic Targets in Melanoma ...................................... 1
Michael J. Murphy
2 Diagnostic and Prognostic Biomarkers in Melanoma:
Current State of Play ................................................................... 9
Jochen Utikal, Jürgen C. Becker, and Selma Ugurel
3 Molecular Pathogenesis of Melanoma: Established
and Novel Pathways ..................................................................... 19
Paolo Antonio Ascierto, Maria Libera Ascierto,
Mariaelena Capone, Zendee Elaba, Michael J. Murphy,
and Giuseppe Palmieri
4 Staging of Melanoma ................................................................... 39
Zendee Elaba, Michael J. Murphy, Philip Kerr,
and Jane M. Grant-Kels
5 Clinical and Histopathological Parameters in Melanoma ....... 49
Cheryl Bilinski, Avery LaChance, and Michael J. Murphy
6 Genetic/Epigenetic Biomarkers: Distinction of Melanoma
from Other Melanocytic Neoplasms ........................................... 69
Minoru Takata
7 mRNA Biomarkers in Melanoma ............................................... 79
Giovanna Chiorino and Maria Scatolini
8 Epigenetic Biomarkers in Melanoma ......................................... 89
Suhu Liu, Suping Ren, Paul M. Howell Jr., and Adam I. Riker
9 MicroRNA Biomarkers in Melanoma ........................................ 113
Jim Kozubek, Faseeha Altaf, and Soheil Sam Dadras
10 MicroRNAs as Biomarkers and Therapeutic Targets
in Melanoma ................................................................................. 127
Daniel W. Mueller and Anja K. Bosserhoff
11 Mitochondrial DNA Biomarkers in Melanoma ......................... 145
Mark L. Steinberg
Contents
x Contents
12 Tissue-Based Protein Biomarkers in Melanoma:
Immunohistochemistry: (A) Diagnosis ...................................... 159
Steven J. Ohsie, Basil A. Horst, Alistair Cochran,
and Scott W. Binder
13 Tissue-Based Protein Biomarkers in Melanoma:
Immunohistochemistry: (B) Prognostication ............................ 177
Basil A. Horst, Steven J. Ohsie, Alistair Cochran,
and Scott W. Binder
14 Tissue-Based Protein Biomarkers in Melanoma:
Mass Spectrometry-Based Strategies ......................................... 189
Michael J. Murphy, Karim Rezaul, and David K. Han
15 Serological Biomarkers in Melanoma ........................................ 195
Mel Ziman, Michael Millward, Robert Pearce,
and Mark Lee
16 Molecular Markers of Lymph Node Disease in Melanoma ..... 209
Sandro Pasquali, Augustinus P.T. van der Ploeg,
and Simone Mocellin
17 Melanoma Cell Propagation: Cancer Stem Cell, Clonal
Evolution and Interconversion Models of Tumorigenicity ....... 227
Qiuzhen Liu, Marianna Sabatino, David F. Stroncek,
Ping Jin, Francesco M. Marincola, and Ena Wang
18 Surgical Management of Melanoma: Concept of Field
Cancerization and Molecular Evaluation
of Tissue Margins ......................................................................... 243
Amanda Phelps and Michael J. Murphy
19 Chemotherapy for Melanoma ..................................................... 247
Hedwig Stanisz, Thomas Vogt, and Knuth Rass
20 Molecular-Targeted Therapy for Melanoma ............................. 265
Alessia E. Russo, Ylenia Bevelacqua, Andrea Marconi,
Andrea Veronesi, and Massimo Libra
21 Anti-Angiogenesis Therapy for Melanoma................................ 281
Roberta Ferraldeschi and Paul Lorigan
22 Immunological Biomarkers and Immunotherapy
for Melanoma ............................................................................... 295
Jochen T. Schaefer
23 Diagnostic and Prognostic Biomarkers and Therapeutic
Targets in Melanoma: An Overview .......................................... 305
Ahmad A. Tarhini and John M. Kirkwood
Index ...................................................................................................... 319
 

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