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Hemophilia and Von Willebrand Disease

Factor VIII and Von Willebrand Factor

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Autore: Green
Editore: Elsevier
Anno: 2018
Pagine: 286
ISBN: 9780128129548
Prezzo: 61,00€
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I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

Features:

  • Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articles
  • Combines the multi-disciplinary research that is generated from Factor VIII/Von Willebrand Factor – hematology, drug discovery, genetics, cell biology, and oncology
  • Delves into unanswered questions and future directions of this important blood-clotting complex

1. Historical Background
2. Factor VIII: Anatomy and Physiology
A. Isolation & Relationship to the Von Willebrand Factor
B. Structure
C. Cell of Origin, Secretion, & Clearance
D. Participation in Hemostasis & Inactivation

3. Genetic Basis of Hemophilia
A. Factor VIII gene
B. Mutations
C. Hemophilia in Women
D. Carrier Detection & Prenatal Diagnosis

4. Factor VIII Therapy for Bleeding
A. Plasma and Cryoprecipitate
B. Recombinant Factor VIII
C. Gene Therapy

5. Complications of Therapy
A. Allergic Reactions
B. Thrombosis
C. Alloantibodies

6. Acquired Disorders of Factor VIII
A. Autoantibodies
B. Non-immunologic

7. Factor VIII and Thrombosis
A. Genetic disorders
B. Hormones
C. Role in Thrombosis
D. Antithrombotic Therapy

8. Factor VIII: Future Directions
A. Re-engineering FVIII for oral or topical administration
B. Decreasing FVIII immunogenicity
C. Anti-thrombotics that block FVIII
D. Genetic and cell-based approaches

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